MyBioSource Launches Validated Anti-CALB2 Antibody for Neuroscience Research
MyBioSource has introduced a validated sheep anti-rat calretinin polyclonal antibody that enables advanced research into calcium signaling, neuroprotection, and neurodegeneration across multiple species.
MyBioSource, a leader in delivering highly validated life science reagents, has added a sheep anti-rat calretinin polyclonal antibody to their catalog for advanced research applications. The antibody, designated MBS502148, targets calretinin (CALB2), a vital calcium-binding protein with significant implications in neurobiology and cellular calcium signaling research.
Calretinin, with a molecular weight of 29kDa, is predominantly expressed in nerve cells throughout the central nervous system, retina, and other tissues. Its role in buffering intracellular calcium and maintaining cellular homeostasis, along with its contribution to neuroprotection, makes it essential for researchers studying neurological mechanisms. The anti-CALB2 antibody supplied by MyBioSource recognizes rat calretinin protein and offers potential cross-reactivity with mouse, human, and non-human primate calretinin due to 100% sequence homology.
The antibody features sheep polyclonal antibodies that specifically target calretinin protein at approximately 29 kDa, confirmed by Western blot analysis of rat brain lysate. It is purified using Protein A purification for high specificity and low background noise, ensuring reliable research outcomes. Researchers can utilize this antibody across multiple validated techniques including Western Blot, Immunohistochemistry on formalin or paraformaldehyde perfused rat brain tissues, and Immunofluorescence applications.
This research-specific antibody is particularly valuable for neuroscience studies involving neurodegeneration, calcium signaling mechanisms, cellular calcium buffering processes, and auditory neuron research. The cross-species reactivity makes it suitable for investigations using mouse, human, and non-human primate samples, expanding its utility across various research models. Calretinin serves as an important marker in neurological studies, particularly in analyzing calcium dynamics and neuronal resistance to excitotoxicity.
The antibody is stable at -20°C, though researchers must avoid repeated freeze/thaw cycles to maintain optimal performance. It is intended for research use only and is not suitable for diagnostic, therapeutic, or clinical applications. Researchers are advised to follow appropriate laboratory safety guidelines and validate antibody performance under their specific experimental conditions. This addition to MyBioSource's catalog supports academicians and researchers focused on elucidating calcium regulation mechanisms, neuronal function, and related biological pathways while contributing to literature review in neurodegeneration, auditory neuroscience, and developmental biology studies.