National Survey Reveals Nearly Half of US Adults Experience Unexplained or Treatment-Resistant Pain and Illness

A groundbreaking national survey to be presented at the Association for the Treatment of Neuroplastic Symptoms conference shows that 40% of Americans seeking medical care have symptoms likely caused by stress-induced neural pathway changes rather than structural issues.

September 8, 2025
National Survey Reveals Nearly Half of US Adults Experience Unexplained or Treatment-Resistant Pain and Illness

The Association for the Treatment of Neuroplastic Symptoms will host its national conference from September 28-30 in Boulder, Colorado, where medical professionals will address what new research identifies as a widespread health crisis affecting nearly half of American adults. According to a first-of-its-kind national survey to be presented at the conference, 40% of people who visit doctors experience pain or illness that is either unexplained or not responding to conventional treatments, with neuroplastic symptoms likely affecting the majority of this group.

Neuroplastic symptoms result from stress-induced changes in nerve pathways within the brain rather than from injury or disease. These conditions include fibromyalgia, migraines, irritable bowel syndrome, chronic back pain, many long COVID cases, and dozens of other disorders. Dr. David Clarke, president of the ATNS, emphasized the significance of the findings, stating that this survey addresses critical questions affecting a substantial portion of the population seeking medical care.

The conference will feature more than 40 leading experts discussing Neuroplastic Recovery Therapy, an evidence-based, biopsychosocial approach that focuses on uncovering stress, trauma, and unrecognized emotions that contribute to these conditions. Unlike traditional treatments that often involve drugs, surgery, or expensive procedures, this method enables patients to achieve healing by understanding and addressing the neural patterns learned in response to adversity, frequently beginning in childhood.

Dr. Clarke noted that Neuroplastic Recovery Therapy is supported by gold-standard scientific research from randomized trials published in top medical journals such as the American Medical Association Psychiatry journal. The ATNS, a 501(c)(3) nonprofit organization, is dedicated to ending the chronic pain epidemic by promoting awareness, diagnosis, and treatment of neuroplastic pain and illness through safer, more affordable, and more effective methods than conventional approaches.

This conference represents a pivotal moment in addressing a significant public health issue, offering new hope for millions suffering from chronic conditions that have often been misunderstood or inadequately treated by the medical establishment.